Investigating how a protein affects blood vessel growth and metabolism in cells
Mitochondria Dynamics Protein Drp1 in ROS Signaling, Endothelial Metabolism and Angiogenesis
This study is looking at how a protein called Drp1 helps new blood vessels grow, especially in people with peripheral arterial disease (PAD) and diabetes, by understanding how a substance called hydrogen peroxide affects the energy of the cells that line our blood vessels, with the hope of finding new ways to improve blood flow in damaged areas.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-10887460 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called Drp1 in the signaling process that promotes the growth of new blood vessels, particularly in conditions like peripheral arterial disease (PAD) which is often worsened by diabetes. The study aims to uncover how reactive oxygen species (ROS), specifically hydrogen peroxide, influence this process by regulating the metabolism of endothelial cells, which line blood vessels. By exploring the connection between ROS signaling and endothelial cell energy production, the research seeks to identify new therapeutic strategies for enhancing blood vessel formation in damaged tissues.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from peripheral arterial disease, particularly those with diabetes.
Not a fit: Patients with conditions unrelated to blood vessel growth or those not experiencing issues with angiogenesis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood vessel growth and healing in patients with conditions like PAD.
How similar studies have performed: Previous research has shown promising results in understanding the role of ROS in angiogenesis, suggesting that this approach could yield valuable insights.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Ushio-Fukai, Masuko — Augusta University
- Study coordinator: Ushio-Fukai, Masuko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.