Investigating how a protein affects blood vessel cells in lung disease
Role of Epigenetic Regulator SIN3a in Pulmonary Endothelial Cells
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10990338
This study is looking at a protein called SIN3a in lung cells to see how it affects another protein that helps keep your blood vessels healthy, with the hope of finding new treatments for people with pulmonary arterial hypertension (PAH).
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10990338 on ClinicalTrials.gov |
What this research studies
This research focuses on pulmonary arterial hypertension (PAH), a serious lung condition that leads to high blood pressure in the lungs and can cause heart failure. The study examines the role of a protein called SIN3a in pulmonary endothelial cells, which are crucial for maintaining healthy blood vessels. By understanding how SIN3a influences the gene that regulates another important protein, BMPR2, the research aims to uncover new therapeutic strategies to restore normal function in these cells. Patients may benefit from insights that could lead to innovative treatments for PAH.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension, particularly those with mutations affecting the BMPR2 gene.
Not a fit: Patients with pulmonary arterial hypertension who do not have any genetic mutations related to BMPR2 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve the health and survival of patients with pulmonary arterial hypertension.
How similar studies have performed: Previous research has shown promising results in targeting epigenetic regulators for therapeutic purposes, suggesting potential success for this approach.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HADRI, LAHOUARIA — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: HADRI, LAHOUARIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.