Investigating how a protein affects abdominal aortic aneurysms
Role of CLCA1 as a MIF decoy inhibitor in abdominal aortic aneurysms
This study is looking at how a protein called CLCA1 works with another protein to understand what happens in abdominal aortic aneurysms, which could help find better treatments for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11063238 on NIH RePORTER |
What this research studies
This research focuses on the role of a protein called CLCA1 in the development of abdominal aortic aneurysms (AAA). Researchers will explore how CLCA1 interacts with another protein, macrophage migration inhibitory factor (MIF), to understand its potential impact on the disease. By studying mouse aortic smooth muscle cells and using advanced biochemical techniques, the team aims to uncover new mechanisms that could lead to better treatments for AAA. Patients may benefit from insights gained about the biological processes involved in this serious condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for abdominal aortic aneurysms, particularly those with a history of cardiovascular disease.
Not a fit: Patients who do not have abdominal aortic aneurysms or related cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating abdominal aortic aneurysms.
How similar studies have performed: Previous research has shown promising results in understanding the role of MIF in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Libby, Peter — Brigham and Women's Hospital
- Study coordinator: Libby, Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.