Investigating how a new RNA affects cancer caused by arsenic exposure
circSATB2, a novel regulator of arsenic-induced carcinogenesis
['FUNDING_R01'] · VAN ANDEL RESEARCH INSTITUTE · NIH-11007210
This study is looking at how a common toxin called inorganic arsenic might lead to cancer and is exploring a special type of RNA that could help protect important genes; the findings could help develop new treatments for people affected by arsenic-related cancers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VAN ANDEL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (GRAND RAPIDS, UNITED STATES) |
| Trial ID | NIH-11007210 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how inorganic arsenic, a common environmental toxin, contributes to cancer development. It examines the role of a newly discovered circular RNA, circSATB2, which may protect certain cancer-related genes from degradation. By studying the effects of arsenic on DNA and chromatin structure, the research aims to uncover new mechanisms of arsenic-induced oncogenesis. Patients may benefit from insights that could lead to novel therapeutic strategies for arsenic-related cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to inorganic arsenic and are at risk for developing related cancers.
Not a fit: Patients who have not been exposed to arsenic or do not have arsenic-related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or preventive measures for cancers caused by arsenic exposure.
How similar studies have performed: Other research has shown promising results in understanding the molecular mechanisms of arsenic-induced carcinogenesis, but the specific approach of targeting circSATB2 is relatively novel.
Where this research is happening
GRAND RAPIDS, UNITED STATES
- VAN ANDEL RESEARCH INSTITUTE — GRAND RAPIDS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FONDUFE-MITTENDORF, YVONNE NSOKIKA — VAN ANDEL RESEARCH INSTITUTE
- Study coordinator: FONDUFE-MITTENDORF, YVONNE NSOKIKA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: arsenic induced cancer