Investigating how a new factor influences liver cancer linked to obesity
A Role for the Novel HAF-NFkappaB Axis in Driving Obesity-Associated Liver Cancer
This study is looking at how a new factor called HAF affects liver cancer that can happen with obesity, and it's for people who want to understand more about how their weight might influence liver health and cancer risks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10911902 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a novel factor called HAF in the development of liver cancer associated with obesity. It examines how HAF interacts with specific proteins in the NF-κB signaling pathway, which is crucial for cell survival and inflammation. By studying mouse models and cancer cells, the researchers aim to uncover the mechanisms by which HAF loss contributes to liver cancer progression, particularly in the context of metabolic diseases like fatty liver disease. The findings could lead to new diagnostic and treatment strategies for patients suffering from liver cancer linked to obesity.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with obesity-related liver conditions, particularly those at risk for hepatocellular carcinoma.
Not a fit: Patients without obesity or liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve outcomes for patients with liver cancer associated with obesity.
How similar studies have performed: Other research has shown promising results in targeting similar pathways in cancer treatment, suggesting potential for success in this novel approach.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Koh, Mei Yee — University of Utah
- Study coordinator: Koh, Mei Yee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.