Investigating how a new enzyme affects aging and health
Impact of a Novel Secreted Enzyme J18 on Healthspan and Lifespan
This study is looking at a special enzyme in saliva called J18 to see how it affects health and aging, especially in older adults, by checking its levels during different metabolic conditions like fasting and obesity, with hopes of finding ways to improve health as we age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11051160 on NIH RePORTER |
What this research studies
This research focuses on a novel enzyme called J18, which is secreted in saliva and plays a role in metabolism and aging. The study aims to understand how J18 influences healthspan and lifespan, particularly in older adults. Researchers will analyze the levels of J18 in different metabolic states, such as fasting and obesity, using mouse models to gather insights that may apply to humans. By exploring the effects of J18 on metabolic health, the research seeks to uncover potential interventions that could improve health outcomes for aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are interested in metabolic health and aging.
Not a fit: Patients under the age of 65 or those with specific metabolic disorders unrelated to aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing health and longevity in older adults.
How similar studies have performed: While the specific enzyme J18 is novel, similar research on metabolic health and aging has shown promising results in other studies.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Zhao, Shangang — University of Texas Hlth Science Center
- Study coordinator: Zhao, Shangang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.