Investigating how a new compound affects brain health and iron balance in neurodegenerative diseases.
A Mechanistic Foundation for the Iron Homeostasis Impacts and Neurotrophic Activity of trans-Banglene
['FUNDING_R21'] · UNIVERSITY OF IOWA · NIH-10984777
This study is looking at how a small molecule called trans-banglene (t-BG) might help improve brain health and manage symptoms in people with neurodegenerative diseases like Alzheimer's by promoting brain cell growth and balancing iron levels.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10984777 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a small molecule called trans-banglene (t-BG) can influence brain health and iron levels in patients with neurodegenerative diseases like Alzheimer's. The study aims to explore how t-BG interacts with brain cells and its potential to promote cell survival and growth. By examining its effects on iron-binding proteins and neurotrophic responses, the researchers hope to uncover new insights into treating conditions that currently have limited therapeutic options. Patients may benefit from this research if t-BG proves effective in improving brain function and managing symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those with the APOE ε4 allele.
Not a fit: Patients with neurodegenerative diseases not related to Alzheimer's or those without the APOE ε4 allele may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve brain health and slow the progression of neurodegenerative diseases.
How similar studies have performed: While the specific compound t-BG is novel, similar approaches targeting neurotrophic factors and iron homeostasis have shown promise in other studies.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WILLIAMS, FLORENCE JUDITH — UNIVERSITY OF IOWA
- Study coordinator: WILLIAMS, FLORENCE JUDITH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia