Investigating how a neurotransmitter affects blood cell production during stress.
The role of NPY in stress-induced hematopoiesis
This study is looking at how a substance called neuropeptide Y (NPY) affects the production of blood cells, especially when patients are dealing with stress from treatments like chemotherapy or radiation, to find ways to help improve recovery for those getting stem cell transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11040983 on NIH RePORTER |
What this research studies
This research explores the role of neuropeptide Y (NPY) in the production of blood cells, particularly under stress conditions such as those caused by chemotherapy or radiation therapy. It aims to understand how NPY influences the bone marrow environment, which is crucial for the health and function of hematopoietic stem and progenitor cells (HSPCs). By studying the effects of NPY on blood cell formation, the research seeks to identify potential therapeutic strategies to improve outcomes for patients undergoing hematopoietic stem cell transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with hematological malignancies or those who have experienced bone marrow failure due to chemotherapy or radiation.
Not a fit: Patients with stable blood cell production and no history of bone marrow damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for enhancing blood cell production in patients undergoing treatments that damage bone marrow.
How similar studies have performed: Previous research has shown promising results in understanding the role of neuronal signals in hematopoiesis, suggesting that this approach may lead to significant advancements.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Singh, Pratibha — Indiana University Indianapolis
- Study coordinator: Singh, Pratibha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.