Investigating how a neuropeptide affects cocaine reward suppression
Official title: Mesolimbic Nociceptin Signaling and Cocaine Reward Suppression
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11112459 · Data updated 2026-11-12
This study is looking at how a brain chemical called nociceptin might help reduce the pleasure people get from cocaine, and it’s using animal models to figure out how this works, which could lead to new ways to help those struggling with cocaine addiction.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | June 15, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $209,375 |
| NIH project number | 5R21DA058804-02 |
| Project ID | NIH-11112459 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with cocaine addiction or those at risk of developing cocaine dependence.
✕Less likely to help
Patients who are not addicted to cocaine or do not have a history of substance use disorders may not benefit from this research.
What this research studies
This research explores the role of a neuropeptide called nociceptin in suppressing the rewarding effects of cocaine. By using advanced techniques such as optogenetics and genetic tools, the study aims to understand how nociceptin signaling in specific brain regions influences addiction behaviors. The research will involve detailed analysis in animal models to uncover the mechanisms behind cocaine reward suppression, which could lead to new treatment strategies for cocaine addiction.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help individuals overcome cocaine addiction by targeting specific brain signaling pathways.
How similar studies have gone: While the specific approach of targeting nociceptin signaling is relatively novel, similar studies have shown promise in understanding addiction mechanisms and developing potential treatments.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Melikian, Haley E — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Melikian, Haley E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.