Investigating how a neuron-derived signal affects brain immune cells during development
Official title: Neuron-Microglia Crosstalk in Development: A new role for the neuron-derived cytokine IL34 in microglial function
Funded at Duke University · NIH-10994156 · Data updated 2026-11-12
This study is looking at how a special signal called IL34 helps brain immune cells called microglia work during important times of brain development, which could help us understand how problems in these processes might lead to conditions that affect brain growth and function.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | December 1, 2022 |
| Project end | September 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $44,270 |
| NIH project number | 5F31NS130757-03 |
| Project ID | NIH-10994156 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old who may be experiencing neurodevelopmental issues or are at risk for Alzheimer's disease.
✕Less likely to help
Patients who are over 21 years old or do not have neurodevelopmental concerns may not benefit from this research.
What this research studies
This research explores the interaction between neurons and microglia, which are immune cells in the brain, focusing on a specific signal called IL34. The study aims to understand how IL34 influences microglial function during critical periods of brain development, particularly in the formation of synaptic connections. By examining the effects of neuronal activity on IL34 expression, the research seeks to uncover the mechanisms that regulate microglial behavior and their role in brain plasticity. This could provide insights into how disruptions in these processes may contribute to neurodevelopmental disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions like Alzheimer's disease by targeting the interactions between neurons and microglia.
How similar studies have gone: Previous research has shown promising results in understanding microglial function and its implications for neurodevelopment, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Devlin, Benjamin — Duke University
- Study coordinator: Devlin, Benjamin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.