Investigating how a multi-enzyme complex affects the secretion of specific lipoproteins linked to heart disease.
Role of Multi-enzyme Complex in ApoBCL Secretion
This study is looking at how certain enzymes in the liver help control the production of fats that can raise your cholesterol and triglyceride levels, with the hope of finding better ways to manage heart health for people at risk of cardiovascular disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11004399 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a multi-enzyme complex in the secretion of triglyceride-rich lipoproteins, which are associated with cardiovascular disease risk. The study aims to characterize a new regulatory mechanism that influences the synthesis of fatty acids and triglycerides in the liver. By examining the interactions and locations of key enzymes involved in lipid metabolism, the research seeks to uncover how these processes contribute to elevated levels of harmful lipoproteins in the blood. Patients may benefit from insights that could lead to improved treatments for managing cholesterol and triglyceride levels.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with elevated triglyceride levels or those at risk for cardiovascular disease despite current treatments.
Not a fit: Patients with normal triglyceride levels and no cardiovascular risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for reducing cardiovascular disease risk in patients with high triglyceride levels.
How similar studies have performed: Previous research has shown that targeting lipid metabolism can effectively reduce cardiovascular risk, suggesting that this approach may also yield beneficial results.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Horton, Jay D. — Ut Southwestern Medical Center
- Study coordinator: Horton, Jay D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.