Investigating how a molecular machine called condensin affects gene regulation and chromosome structure.
Official title: The gene regulatory functions of condensin
Funded at University of Michigan at Ann Arbor · NIH-11032893 · Data updated 2026-11-12
This study is looking at how a special protein complex called condensin helps organize our chromosomes and affects how genes work during cell division, using tiny worms called C. elegans, and the results could help us understand some developmental disorders and cancers related to problems with this protein.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $338,800 |
| NIH project number | 5R35GM149543-03 |
| Project ID | NIH-11032893 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with developmental disorders or cancers that may be linked to mutations in the condensin complex.
✕Less likely to help
Patients without chromatin-related disorders or those not affected by the specific gene regulation issues studied may not benefit from this research.
What this research studies
This research focuses on understanding the role of a molecular complex known as condensin in the organization and regulation of chromosomes. By studying the model organism C. elegans, the research aims to uncover how condensin influences gene expression and chromosome segregation during cell division. The project will explore the mechanisms by which condensin alters chromatin structure, which is crucial for proper development and function of cells. Findings from this research could provide insights into developmental disorders and cancers linked to condensin mutations.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating developmental abnormalities and cancers associated with chromatin structure defects.
How similar studies have gone: Previous research has shown that understanding chromatin structure and gene regulation can lead to significant advancements in treating related diseases, indicating that this approach has potential for success.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Csankovszki, Gyorgyi — University of Michigan at Ann Arbor
- Study coordinator: Csankovszki, Gyorgyi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.