Investigating how a mitochondrial protein may protect against Alzheimer's disease.
Protective Role of Mitochondrial CHCHD10 in Alzheimer's Disease through MAM and Mitophagy Mechanisms.
This study is looking at a protein called CHCHD10 and how it might help protect brain cells in people with Alzheimer's by boosting their health and reducing harmful substances, and it’s testing a special treatment that could increase this protein in the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11143673 on NIH RePORTER |
What this research studies
This research focuses on the role of the mitochondrial protein CHCHD10 in Alzheimer's disease, particularly how it interacts with mitochondrial functions and the accumulation of amyloid beta. The study aims to evaluate the therapeutic potential of specific small DNA oligos that can increase CHCHD10 levels in brain cells, potentially reducing the harmful effects associated with Alzheimer's. By using animal models and human cell lines, the research will explore the mechanisms of mitophagy and the relationship between CHCHD10 and mitochondrial health in the context of Alzheimer's pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that protect brain cells from damage in Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting mitochondrial dysfunction in Alzheimer's, suggesting potential for success in this approach.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Liu, Tian — Case Western Reserve University
- Study coordinator: Liu, Tian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.