Investigating how a mitochondrial protein affects the creation of ribosomes in cells.
Defining a role for the mitochondrial protein sulfite oxidase in nucleolar ribosome biogenesis
This study is looking at how a protein called sulfite oxidase (SUOX) helps make ribosomes, which are important for cell function, especially in breast cells, and it hopes to find new ways to help patients with conditions like cancer by understanding this process better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10909854 on NIH RePORTER |
What this research studies
This research explores the role of the mitochondrial protein sulfite oxidase (SUOX) in the process of ribosome biogenesis, which is crucial for cell function. By using advanced techniques such as genome-wide siRNA screening, the study aims to identify how SUOX influences the number of nucleoli in cells, particularly in breast epithelial cells. The research focuses on understanding the implications of SUOX on ribosomal RNA production and its potential links to diseases like cancer and ribosomopathies. Patients may benefit from insights gained about ribosome production and its regulation, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and young individuals under 21 years old who may be affected by conditions related to ribosome biogenesis.
Not a fit: Patients with conditions unrelated to ribosome biogenesis or mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases related to ribosome dysfunction, such as certain cancers.
How similar studies have performed: Other research has shown promising results in understanding ribosome biogenesis, making this approach both relevant and potentially impactful.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Sutton, Emily Catherine — Yale University
- Study coordinator: Sutton, Emily Catherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.