Investigating how a mitochondrial protein affects pancreatic cancer spread and gene regulation
Official title: Defining the role of the mitochondrial protein, GOT2, in pancreatic cancer metastasis and epigenetic dysregulation
Funded at Oregon Health & Science University · NIH-10999039 · Data updated 2026-11-12
This study is looking at how a protein called GOT2 affects the spread of pancreatic cancer and how it might change the way cancer cells behave, which could help us find better treatments for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | September 9, 2024 |
| Project end | November 8, 2027 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 1F31CA288079-01A1 |
| Project ID | NIH-10999039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic adenocarcinoma, particularly those with advanced stages of the disease.
✕Less likely to help
Patients with early-stage pancreatic cancer or those with other types of cancer may not receive direct benefits from this research.
What this research studies
This research focuses on pancreatic adenocarcinoma, a highly aggressive cancer with a poor prognosis. The team is exploring the role of the mitochondrial protein GOT2 in the metastasis of this cancer and its potential impact on epigenetic changes. Using mouse models, they aim to understand how GOT2 influences tumor development and the immune environment, which could lead to new insights into treatment strategies. Patients may benefit from findings that could improve understanding of cancer progression and treatment resistance.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for pancreatic cancer, potentially improving patient outcomes.
How similar studies have gone: Previous studies have shown promising results in understanding the role of mitochondrial proteins in cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Diaz, Luis Francisco — Oregon Health & Science University
- Study coordinator: Diaz, Luis Francisco
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.