Investigating how a metabolite called β-hydroxybutyrate affects Alzheimer's disease and aging.
Mechanisms of the signaling metabolite β-hydroxybutyrate in Alzheimer's disease and the aging brain
This study is looking at how a substance called β-hydroxybutyrate (BHB), which your body makes when you fast or exercise, might help improve memory and brain health in older adults with Alzheimer's disease by exploring the effects of a special diet that increases BHB levels.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Buck Institute for Research on Aging NIH-funded |
| Lab location | 1 site (Novato, United States) |
| Project ID | NIH-10884353 on NIH RePORTER |
What this research studies
This research explores the role of β-hydroxybutyrate (BHB), a signaling metabolite that is produced during fasting and exercise, in the context of Alzheimer's disease and aging. The study aims to understand how BHB influences cellular functions related to energy metabolism, inflammation, and gene expression, which are critical in the aging process and cognitive decline. By examining the effects of a ketogenic diet that boosts BHB levels, the research seeks to uncover potential therapeutic benefits for memory and cognitive function in older adults. Participants may benefit from insights into dietary interventions that could enhance brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above, particularly those experiencing cognitive decline or Alzheimer's disease.
Not a fit: Patients under the age of 65 or those without cognitive impairment may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary strategies that improve memory and cognitive function in older adults and those with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results with ketogenic diets in animal models of Alzheimer's disease, indicating potential for success in human studies.
Where this research is happening
Novato, United States
- Buck Institute for Research on Aging — Novato, United States (Active)
Researchers
- Principal investigator: Newman, John C — Buck Institute for Research on Aging
- Study coordinator: Newman, John C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.