Investigating how a medication can activate fat tissue in older adults
Mechanisms for activation of beige adipose tissue in humans
This study is looking at how the medication mirabegron, usually used for overactive bladder, might help older adults by changing fat tissue in a way that could improve their blood sugar and insulin levels over a 4-month trial.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10746421 on NIH RePORTER |
What this research studies
This research explores the effects of mirabegron, a medication typically used for overactive bladder, on fat tissue in older adults. The study focuses on how this drug can induce a process called 'beiging' in subcutaneous white adipose tissue, which may improve glucose metabolism and insulin sensitivity. Participants will undergo a 4-month trial where their glucose tolerance and insulin function will be closely monitored. The goal is to understand the indirect mechanisms through which mirabegron benefits metabolic health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are obese and insulin resistant.
Not a fit: Patients who are not obese or do not have insulin resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for improving glucose metabolism in older adults, potentially reducing the risk of diabetes.
How similar studies have performed: Previous research has shown promising results with similar approaches using β3 adrenergic receptor agonists for metabolic improvements.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Kern, Philip a — University of Kentucky
- Study coordinator: Kern, Philip a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.