Investigating how a liver protein affects fat tissue inflammation and metabolism
THE ROLE OF HEPATOKINE ORM2 IN ADIPOSE TISSUE INFLAMMATION
This study is looking at how a liver protein called ORM2 affects inflammation and metabolism in fat tissue, which could help improve insulin sensitivity for people dealing with obesity and type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11085088 on NIH RePORTER |
What this research studies
This research explores the role of a liver protein called ORM2 in regulating inflammation and metabolism in fat tissue, particularly in the context of obesity and type 2 diabetes. By using mouse models, the study aims to understand how increased levels of ORM2 can influence fat tissue function and improve insulin sensitivity. The researchers will conduct various metabolic interventions to assess the effects of ORM2 on fat tissue and its potential anti-inflammatory properties. This work could provide insights into new therapeutic approaches for managing obesity-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from obesity or type 2 diabetes who may benefit from improved metabolic health.
Not a fit: Patients who do not have obesity or type 2 diabetes may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation in fat tissue and improve insulin sensitivity for patients with obesity and type 2 diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the metabolic roles of liver proteins in obesity and diabetes, suggesting that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Kim, Kangho — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Kim, Kangho
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.