Investigating how a lactate-derived molecule affects energy balance and communication between tissues
Official title: Role of a lactate-derived signaling metabolite in tissue crosstalk and energy balance
Funded at Stanford University · NIH-10869980 · Data updated 2026-11-12
This study is looking at how a substance called Lac-Phe, which comes from lactate in our bodies, might help control our energy levels and eating habits, with the hope that it can lead to better ways to manage weight and diabetes for people who need it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $491,652 |
| NIH project number | 5R01DK136526-02 |
| Project ID | NIH-10869980 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with adult-onset diabetes or those struggling with obesity and related metabolic disorders.
✕Less likely to help
Patients with conditions unrelated to energy metabolism or those not experiencing issues with weight or diabetes may not benefit from this research.
What this research studies
This research explores the role of lactate, a substance produced during metabolism, in regulating energy balance and communication between different tissues in the body. It focuses on a specific metabolite derived from lactate called Lac-Phe, which has been shown to influence feeding behavior and obesity. By conducting biochemical and physiological studies, the research aims to understand how Lac-Phe functions as a signaling molecule that can affect energy homeostasis. Patients may benefit from insights gained about how to manage conditions related to energy metabolism, such as obesity and diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing obesity and diabetes by targeting lactate-derived signaling pathways.
How similar studies have gone: Previous studies have shown promising results regarding the role of lactate in metabolism, suggesting that this research could build on established findings.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Long, Jonathan Z — Stanford University
- Study coordinator: Long, Jonathan Z
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.