Investigating how a kidney protein helps protect against sepsis
Official title: The protective role of kidney-derived Tamm Horsfall protein (Uromodulin) in sepsis
Funded at Indiana University Indianapolis · NIH-10900656 · Data updated 2026-11-12
This study is looking at how a protein made by the kidneys, called Tamm Horsfall Protein, might help protect the body during severe infections like sepsis, especially for people who also have kidney problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $239,040 |
| NIH project number | 5R00DK127216-04 |
| Project ID | NIH-10900656 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who are experiencing sepsis, particularly those with or at risk for acute kidney injury.
✕Less likely to help
Patients who do not have sepsis or acute kidney injury may not benefit from this research.
What this research studies
This research focuses on understanding the role of Tamm Horsfall Protein (THP), a protein produced by the kidneys, in protecting the body during sepsis, a severe infection response. The study aims to explore how THP may enhance immune function and improve outcomes for patients experiencing acute kidney injury (AKI) in the context of sepsis. By examining both human and animal models, the researchers will investigate the mechanisms through which THP operates and its potential protective effects on other organs during severe infections.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve survival rates and outcomes for patients suffering from sepsis and acute kidney injury.
How similar studies have gone: Previous studies have shown promising results regarding the protective role of THP in kidney health and immune regulation, suggesting that this approach may be viable.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Lafavers, Kaice — Indiana University Indianapolis
- Study coordinator: Lafavers, Kaice
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.