Investigating how a key protein helps repair DNA damage
Official title: RPA-Directed DNA Repair Mechanisms
Funded at Rowan University School/osteopathic Med · NIH-10982494 · Data updated 2026-11-12
This study is looking at how a protein called RPA helps fix damaged DNA by working with another protein, UNG2, and it’s for anyone interested in understanding how our cells repair their genetic material to stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rowan University School/osteopathic Med NIH-funded |
| Lab location | 1 site (Stratford, United States) |
| Project start | December 1, 2020 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $304,290 |
| NIH project number | 5R01GM135152-05 |
| Project ID | NIH-10982494 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to DNA repair deficiencies or those undergoing treatments that affect DNA integrity.
✕Less likely to help
Patients with no known DNA repair issues or those not affected by conditions related to DNA damage may not benefit from this research.
What this research studies
This research focuses on the role of Replication Protein A (RPA) in DNA repair processes, particularly in how it interacts with other proteins to fix damaged DNA. By creating mini DNA repair complexes that mimic natural interactions in cells, the researchers aim to understand how RPA and Uracil DNA Glycosylase (UNG2) work together. The study involves manipulating these proteins and observing their activities using synthetic DNA substrates to gain insights into their functions at critical DNA junctions. This could lead to a better understanding of DNA repair mechanisms that are essential for maintaining genetic stability.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of DNA repair mechanisms, potentially leading to improved treatments for diseases related to DNA damage, such as cancer.
How similar studies have gone: Other research has shown success in understanding DNA repair mechanisms, making this approach a continuation of established scientific inquiry.
Where this research is happening
-
Rowan University School/osteopathic Med
Stratford, United States Active
Researchers
- Principal investigator: Weiser, Brian Patrick — Rowan University School/osteopathic Med
- Study coordinator: Weiser, Brian Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.