Investigating how a key circadian regulator affects nerve repair and regeneration
Official title: The Role of Core Circadian Regulator Bmal1 in Axonal Regeneration and Nerve Repair
Funded at Icahn School of Medicine at Mount Sinai · NIH-11042826 · Data updated 2026-11-12
This study is looking at how a protein called Bmal1 affects the healing of damaged nerves, with the hope that understanding its role could help develop better treatments for people with nerve injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 15, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $502,613 |
| NIH project number | 5R01NS127442-03 |
| Project ID | NIH-11042826 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced peripheral nerve injuries and are seeking effective treatment options.
✕Less likely to help
Patients with central nervous system injuries or those who do not have peripheral nerve damage may not benefit from this research.
What this research studies
This research explores the role of Bmal1, a core circadian regulator, in the process of axon regeneration following peripheral nerve injuries. The study aims to understand how the deletion of Bmal1 in neurons can accelerate the healing process after such injuries. By examining the molecular mechanisms involved, including the interaction of Bmal1 with other factors that influence gene expression, the research seeks to uncover new pathways that could enhance nerve repair. This could lead to innovative treatments for patients suffering from nerve damage.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that significantly improve nerve regeneration and recovery for patients with peripheral nerve injuries.
How similar studies have gone: Previous research has shown promising results in understanding the molecular mechanisms of nerve regeneration, suggesting that this approach could yield significant insights.
Where this research is happening
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Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Zou, Hongyan Jenny — Icahn School of Medicine at Mount Sinai
- Study coordinator: Zou, Hongyan Jenny
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.