Investigating how a hormone affects food intake and weight control
Effects of mesolimbic amylin signaling on macronutrient intake
This study is looking at how a hormone called amylin affects our eating habits and weight by influencing the brain's reward system, and it aims to find out if these effects are different for men and women, which could help develop new treatments for obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10984486 on NIH RePORTER |
What this research studies
This research explores the role of the hormone amylin in regulating food intake and body weight, particularly focusing on its effects within the brain's reward system. By examining how amylin signaling in the ventral tegmental area influences the consumption of different macronutrients, the study aims to uncover the mechanisms behind its appetite-suppressing effects. Additionally, the research will investigate potential differences in these effects based on sex and hormonal influences, specifically looking at how estradiol may modulate amylin's action. Patients may benefit from insights that could lead to new obesity treatments targeting amylin signaling.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity or those who have difficulty managing their weight.
Not a fit: Patients who are not overweight or obese, or those with eating disorders unrelated to appetite regulation, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for obesity by targeting amylin signaling to help control appetite and promote weight loss.
How similar studies have performed: Previous research has shown promising results in targeting appetite-regulating hormones like amylin for obesity treatment, indicating that this approach has potential for success.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Mietlicki-Baase, Elizabeth Genevieve — State University of New York at Buffalo
- Study coordinator: Mietlicki-Baase, Elizabeth Genevieve
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.