Investigating how a hormone affects blood pressure control in obesity
Angiotensin-(1-7) and Hypothalamic control of blood pressure
This study is looking at how a hormone called angiotensin-(1-7) affects blood pressure in people with obesity, and it aims to find out if boosting this hormone can help lower blood pressure by working with certain brain pathways.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-11055316 on NIH RePORTER |
What this research studies
This research explores the role of angiotensin-(1-7), a hormone that may help regulate blood pressure, particularly in individuals with obesity. The study examines how a deficiency of this hormone can lead to increased sympathetic nervous system activity, which raises blood pressure. By using animal models, the researchers aim to understand how restoring angiotensin-(1-7) can lower blood pressure through specific brain circuits. The findings could provide insights into new treatment strategies for managing hypertension associated with obesity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese and have hypertension or are at risk of developing high blood pressure.
Not a fit: Patients who are not obese or do not have hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for controlling high blood pressure in obese patients.
How similar studies have performed: Previous studies have shown promising results in using hormonal therapies to manage blood pressure, suggesting that this approach may be effective.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Arnold, Amy Christine — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Arnold, Amy Christine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.