Investigating how a high salt diet affects blood pressure regulation
Role of the ubiquitin Ligase adaptor FBXL13 on Salt-sensitive hypertension
['FUNDING_CAREER'] · WAYNE STATE UNIVERSITY · NIH-10830974
This study is looking at how a protein called FBXL13 helps your body handle salt and blood pressure, and it hopes to find new ways to help people with high blood pressure by understanding how a high salt diet affects this protein's work.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAYNE STATE UNIVERSITY (nih funded) |
| Locations | 1 site (DETROIT, UNITED STATES) |
| Trial ID | NIH-10830974 on ClinicalTrials.gov |
What this research studies
This research explores the role of a specific protein, FBXL13, in how the body manages salt intake and blood pressure. The study focuses on understanding whether a high salt diet increases the interaction between FBXL13 and another protein, NKCC2, which may lead to enhanced removal of salt from the body and help prevent high blood pressure. The research aims to develop new strategies for treating hypertension by targeting these protein interactions. Patients may benefit from insights that could lead to better management of their blood pressure through dietary changes or new medications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who experience salt-sensitive hypertension or have high blood pressure issues.
Not a fit: Patients with normal blood pressure or those whose hypertension is not influenced by salt intake may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for managing high blood pressure, improving health outcomes for patients with hypertension.
How similar studies have performed: Previous research has shown promising results in understanding protein interactions related to blood pressure regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
DETROIT, UNITED STATES
- WAYNE STATE UNIVERSITY — DETROIT, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARES-SARMIENTO, GUSTAVO R — WAYNE STATE UNIVERSITY
- Study coordinator: ARES-SARMIENTO, GUSTAVO R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.