Investigating how a heart disease protein affects female fertility
The oocyte's progression through meiosis: Involvement of a heart disease-associated protein
This study is looking at how a protein related to heart disease affects the way eggs develop in women, which is important for fertility, and it aims to find out if this protein could be linked to both infertility and heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-10636839 on NIH RePORTER |
What this research studies
This research focuses on the role of a protein associated with heart disease in the process of meiosis, which is crucial for female fertility. It examines how the organization and positioning of the meiotic spindle in oocytes are influenced by actin and actin-associated proteins. By studying the effects of a specific protein called nexilin, the research aims to understand its impact on oocyte development and its potential links to both infertility and heart conditions. The methodology includes gene knockouts and RNA interference to observe the effects on meiotic progression and actin organization.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing infertility issues, particularly those with a family history of heart disease.
Not a fit: Patients who are male or those who do not have fertility concerns may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into female infertility and potential therapeutic targets for improving reproductive health.
How similar studies have performed: Previous research has shown promising results in understanding the role of actin in cellular processes, suggesting that this approach may yield valuable insights.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Evans, Janice P — Purdue University
- Study coordinator: Evans, Janice P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.