Investigating how a growth factor helps maintain lung health in COPD
Hepatocyte Growth Factor Signaling and Airspace Maintenance
This study is looking at how a protein called hepatocyte growth factor (HGF) might help heal lung damage in people with chronic obstructive pulmonary disease (COPD), with the hope of finding new ways to improve lung health and function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10889917 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of hepatocyte growth factor (HGF) signaling in chronic obstructive pulmonary disease (COPD). The team aims to explore how HGF can promote repair in the lung epithelium, particularly after injuries that simplify airspaces. By studying the interactions between HGF and its receptor, cMet, the researchers hope to uncover new therapeutic approaches that could enhance lung repair and function. The research involves both laboratory studies and preclinical models to assess the effects of HGF signaling on lung health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with chronic obstructive pulmonary disease (COPD).
Not a fit: Patients with other respiratory conditions unrelated to COPD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve lung repair and function in patients with COPD.
How similar studies have performed: Previous studies have shown promising results regarding the role of HGF signaling in lung repair, indicating potential for success in this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Neptune, Enid R — Johns Hopkins University
- Study coordinator: Neptune, Enid R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.