Investigating how a genetic factor affects inflammation in COPD
The role of COPD genetic risk factor HHIP on lymphocytic inflammation
This study is looking at how certain genes, especially the HHIP gene, might affect how severe chronic obstructive pulmonary disease (COPD) can be for different people, helping us understand why some folks struggle more with it than others, even if they have similar smoking backgrounds.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10813180 on NIH RePORTER |
What this research studies
This research explores the genetic factors that influence the severity of chronic obstructive pulmonary disease (COPD), particularly focusing on the HHIP gene. By studying genetic mouse models, the project aims to understand how variations in this gene contribute to inflammation and disease progression in COPD patients. The researchers will analyze immune responses, specifically looking at activated CD8+ T cells, to uncover the cellular and molecular mechanisms involved. This work could lead to better understanding of why some individuals are more susceptible to COPD despite similar smoking histories.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of smoking who have been diagnosed with COPD.
Not a fit: Patients without a history of smoking or those who do not have COPD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies for COPD patients based on their genetic profiles.
How similar studies have performed: Previous research has shown that genetic factors play a significant role in COPD susceptibility, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Yun, Jeong H — Brigham and Women's Hospital
- Study coordinator: Yun, Jeong H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.