Investigating how a gene on the Y chromosome may protect against pulmonary hypertension.
Role of Chromosome Y gene, Uty, in protecting against Pulmonary Hypertension
This study is looking at how a specific gene on the Y chromosome might help protect against pulmonary arterial hypertension (PAH), a lung condition that mainly affects women, using mice to understand how hormones and genetics play a role in this disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10895447 on NIH RePORTER |
What this research studies
This research explores the role of the Uty gene located on the Y chromosome in providing protection against pulmonary arterial hypertension (PAH), a serious lung condition that disproportionately affects women. The study utilizes innovative mouse models to examine how the absence of sex hormones and the presence of the Y chromosome influence the development of PAH. By analyzing lung tissue and macrophages, researchers aim to identify the mechanisms through which Uty may mitigate the effects of this disease, potentially leading to new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension, particularly those who are male.
Not a fit: Patients with pulmonary hypertension who do not have a Y chromosome, such as females, may not directly benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for pulmonary hypertension, improving outcomes for affected patients.
How similar studies have performed: While the investigation of sex chromosomes in PAH is relatively novel, previous studies have shown success in understanding the role of sex hormones in this condition.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Eghbali, Mansoureh — University of California Los Angeles
- Study coordinator: Eghbali, Mansoureh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.