Investigating how a gene linked to autism affects brain development
The Role of the ASD Risk Gene CHD8 in Neural Development
This study is looking at how a specific gene linked to autism affects brain development in zebrafish, which could help us find better ways to diagnose and treat children with autism.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10906033 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the CHD8 gene, which has been strongly associated with autism spectrum disorder (ASD). By using a zebrafish model with a mutation in the chd8 gene, researchers aim to uncover how this mutation impacts the development of neural cells and the overall brain structure. The study will explore the timing and molecular mechanisms of changes in cell cycle progression and neural proliferation, which are crucial for proper brain development. This research could lead to insights that improve early diagnosis and treatment options for children with ASD.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are at risk for or diagnosed with autism spectrum disorder.
Not a fit: Patients outside the age range of 0-11 years or those without a diagnosis or risk factors for autism spectrum disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and targeted treatments for autism spectrum disorder.
How similar studies have performed: Previous research has shown promise in understanding genetic factors in autism, but the specific approach using CHD8 in zebrafish is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Fitzpatrick, Sarah E. — Yale University
- Study coordinator: Fitzpatrick, Sarah E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.