Investigating how a gene linked to Alzheimer's affects brain function in mice
ECM regulation and neuronal plasticity in mice harboring a common risk allele for Alzheimer's
This study is looking at how a specific gene linked to a higher risk of Alzheimer's disease affects brain health and memory, using specially modified mice to see how it influences the removal of a harmful protein and changes in brain structure, with the hope of finding new ways to help people with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11032828 on NIH RePORTER |
What this research studies
This research explores the role of the APOE4 gene, which is known to increase the risk of Alzheimer's disease, in affecting brain function and neuronal plasticity. Using mice that have been genetically modified to carry this gene, the study examines how APOE4 influences the clearance of amyloid-β, a protein associated with Alzheimer's, and its impact on learning and memory. The researchers will analyze changes in brain structure and function, particularly focusing on the extracellular matrix and its role in neuronal health. By understanding these mechanisms, the research aims to uncover potential therapeutic targets for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals with a family history of Alzheimer's disease or those who carry the APOE4 allele.
Not a fit: Patients who do not have a genetic predisposition to Alzheimer's or those with other forms of dementia unrelated to APOE4 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting the underlying mechanisms associated with the APOE4 gene.
How similar studies have performed: Previous research has shown that targeting genetic factors like APOE4 can lead to significant insights into Alzheimer's disease, indicating that this approach has potential for success.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Conant, Katherine E — Georgetown University
- Study coordinator: Conant, Katherine E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.