Investigating how a gene affects the survival of rhabdoid tumors.
Official title: What is the mechanism by which a gene essential for Rhabdoid tumor viability regulates Chromatin function?
Funded at St. Jude Children's Research Hospital · NIH-10997084 · Data updated 2026-11-12
This study is looking at how a certain gene affects the survival of rhabdoid tumors in kids, using cutting-edge technology to find weaknesses in the cancer that could help develop better treatments for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | July 15, 2024 |
| Project end | July 14, 2027 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 1F32CA284882-01A1 |
| Project ID | NIH-10997084 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and young adults diagnosed with rhabdoid tumors.
✕Less likely to help
Patients with other types of tumors or cancers unrelated to rhabdoid tumors may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific gene in the survival of rhabdoid tumors, a type of aggressive pediatric cancer. Using advanced CRISPR technology, researchers will explore how mutations in chromatin remodeling complexes influence gene expression and tumor viability. By comparing rhabdoid tumor cells with other cancer cell lines, the study aims to identify genetic vulnerabilities that could lead to new treatment strategies. Patients may benefit from insights that could improve targeted therapies for this challenging cancer.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with rhabdoid tumors.
How similar studies have gone: Previous research has shown success in using CRISPR technology to identify genetic vulnerabilities in various cancers, suggesting a promising approach for this study.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Cockfield, Jordan a. — St. Jude Children's Research Hospital
- Study coordinator: Cockfield, Jordan a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.