Investigating how a gene affects social behavior and brain function in autism
Official title: Role of neurexin in social adaptation and amygdala plasticity
Funded at Rosalind Franklin Univ of Medicine & Sci · NIH-11160802 · Data updated 2026-11-12
This study is looking at how a specific gene called neurexin affects social behavior and brain connections in people with Autism Spectrum Disorder, using animal models to help us understand why some individuals may struggle with social interactions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rosalind Franklin Univ of Medicine & Sci NIH-funded |
| Lab location | 1 site (North Chicago, United States) |
| Project start | August 5, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $449,104 |
| NIH project number | 5R01MH137651-02 |
| Project ID | NIH-11160802 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Autism Spectrum Disorder or those exhibiting autism-like symptoms.
✕Less likely to help
Patients without autism or autism-like symptoms may not benefit from this research.
What this research studies
This research explores the role of the neurexin gene in social behavior and brain plasticity, particularly in individuals with Autism Spectrum Disorder (ASD). It aims to understand how genetic factors influence social interactions by examining the neural circuits involved in social functioning. The study will utilize animal models to investigate the connections between brain regions that are crucial for social behavior, focusing on how disruptions in the neurexin gene may affect these connections and, consequently, social adaptability. By uncovering these mechanisms, the research seeks to provide insights into the biological underpinnings of social deficits in ASD.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving social functioning in individuals with autism.
How similar studies have gone: Previous research has shown promising results in understanding the genetic influences on social behavior, indicating that this approach has potential for success.
Where this research is happening
-
Rosalind Franklin Univ of Medicine & Sci
North Chicago, United States Active
Researchers
- Principal investigator: Rosenkranz, Jeremy E — Rosalind Franklin Univ of Medicine & Sci
- Study coordinator: Rosenkranz, Jeremy E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.