Investigating how a gene affects protein processing in dementia
Official title: Role of APOE in endosomal processing of alpha-synuclein
Funded at Washington University · NIH-11082106 · Data updated 2026-11-12
This study is looking at how a specific gene called APOE affects a protein linked to dementia, which could help us understand more about diseases like Alzheimer's and Lewy body disease, and it might lead to new treatments for people facing these challenges.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $99,532 |
| NIH project number | 3RF1AG083753-01S1 |
| Project ID | NIH-11082106 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with Lewy body disease or Alzheimer's disease, particularly those with the APOE4 genetic variant.
✕Less likely to help
Patients without dementia or those who do not carry the APOE4 variant may not receive direct benefits from this research.
What this research studies
This research explores the role of the APOE gene in the processing of alpha-synuclein, a protein linked to dementia, particularly in Lewy body disease and Alzheimer's disease. By studying how different variants of the APOE gene influence the aggregation of misfolded proteins in the brain, the research aims to uncover mechanisms that contribute to cognitive decline. The approach includes using mouse models to observe the effects of the APOE4 variant on protein behavior and disease progression. Patients may benefit from insights that could lead to new therapeutic strategies targeting these pathways.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with dementia related to Lewy body disease and Alzheimer's.
How similar studies have gone: Previous research has shown promising results in understanding the role of APOE in Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Davis, Albert a — Washington University
- Study coordinator: Davis, Albert a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.