Investigating how a gene affects protein processing in dementia
Role of APOE in endosomal processing of alpha-synuclein
['FUNDING_OTHER'] · WASHINGTON UNIVERSITY · NIH-11082106
This study is looking at how a specific gene called APOE affects a protein linked to dementia, which could help us understand more about diseases like Alzheimer's and Lewy body disease, and it might lead to new treatments for people facing these challenges.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-11082106 on ClinicalTrials.gov |
What this research studies
This research explores the role of the APOE gene in the processing of alpha-synuclein, a protein linked to dementia, particularly in Lewy body disease and Alzheimer's disease. By studying how different variants of the APOE gene influence the aggregation of misfolded proteins in the brain, the research aims to uncover mechanisms that contribute to cognitive decline. The approach includes using mouse models to observe the effects of the APOE4 variant on protein behavior and disease progression. Patients may benefit from insights that could lead to new therapeutic strategies targeting these pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Lewy body disease or Alzheimer's disease, particularly those with the APOE4 genetic variant.
Not a fit: Patients without dementia or those who do not carry the APOE4 variant may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with dementia related to Lewy body disease and Alzheimer's.
How similar studies have performed: Previous research has shown promising results in understanding the role of APOE in Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAVIS, ALBERT A — WASHINGTON UNIVERSITY
- Study coordinator: DAVIS, ALBERT A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease