Investigating how a gene affects metabolism and behavior in neurofibromatosis type 1
Official title: Genetic and molecular mechanisms of Nf1-dependent neuronal regulation of metabolism
Funded at University of Iowa · NIH-11036334 · Data updated 2026-11-12
This study is looking at how a missing gene related to neurofibromatosis type 1 affects metabolism and behavior, using fruit flies to help us understand the connections between brain function and how our bodies process energy, which could help improve our understanding of the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | October 11, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $349,875 |
| NIH project number | 5R01NS126361-05 |
| Project ID | NIH-11036334 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with neurofibromatosis type 1, particularly those experiencing metabolic or behavioral symptoms.
✕Less likely to help
Patients without neurofibromatosis type 1 or those not experiencing related metabolic issues may not benefit from this research.
What this research studies
This research focuses on neurofibromatosis type 1, a genetic disorder that impacts metabolism and behavior. It aims to understand how the loss of the neurofibromin gene (Nf1) affects metabolic processes in the body. Using a Drosophila model, the study will explore the genes and signaling pathways involved in metabolism regulation and how these changes may contribute to symptoms of the disorder. The findings could provide insights into the relationship between neuronal function and metabolic health.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of metabolic issues associated with neurofibromatosis type 1.
How similar studies have gone: Previous research has shown promising results in understanding genetic influences on metabolism, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Tomchik, Seth M — University of Iowa
- Study coordinator: Tomchik, Seth M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.