Investigating how a fungal pathogen survives oxidative stress
Candida albicans Target of Rapamycin in oxidative stress responses
This study is looking at a special protein in the Candida albicans fungus that helps it survive attacks from our immune system, and by understanding how it works, we hope to find new ways to treat infections caused by this fungus for patients who need help.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11063452 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific protein in the fungus Candida albicans that helps it survive oxidative stress from the host's immune system. The study examines the Tor1 kinase and its N-terminal HEAT repeats, which are crucial for the fungus's ability to manage oxidative stress. By analyzing how these proteins interact and affect the fungus's stress management systems, the research aims to uncover potential vulnerabilities in Candida albicans that could be targeted for treatment. Patients with infections caused by this fungus may benefit from insights gained through this research.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be patients suffering from Candida albicans infections.
Not a fit: Patients with infections caused by other types of fungi or non-fungal pathogens may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for infections caused by Candida albicans.
How similar studies have performed: Other research has shown success in targeting specific pathways in fungal pathogens, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Koehler, Julia R — Boston Children's Hospital
- Study coordinator: Koehler, Julia R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.