Investigating how a feedback loop affects cervical cancer development
Official title: Role of the YAP1-LATS2 negative feedback loop in cervical carcinogenesis
Funded at Massachusetts General Hospital · NIH-11059117 · Data updated 2026-11-12
This study is looking at how certain changes in cells can lead to cervical cancer, especially in women with high-risk HPV, to help find new ways to prevent or treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $487,215 |
| NIH project number | 5R01CA279385-03 |
| Project ID | NIH-11059117 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women diagnosed with high-risk HPV and those with cervical intraepithelial neoplasia.
✕Less likely to help
Patients who do not have cervical cancer or high-risk HPV may not benefit from this research.
What this research studies
This research explores the role of the YAP1-LATS2 negative feedback loop in the development of cervical cancer. It aims to understand how disruptions in this feedback mechanism can lead to the progression of cervical intraepithelial neoplasia and ultimately cervical squamous cell carcinoma. By analyzing genetic and genomic alterations in cervical epithelial cells, the study seeks to identify intrinsic factors that contribute to cancer progression in women with high-risk HPV. The findings could provide insights into potential therapeutic targets for preventing or treating cervical cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for early detection and treatment of cervical cancer, potentially improving survival rates.
How similar studies have gone: Previous research has shown promising results in understanding the role of signaling pathways in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Wang, Cheng — Massachusetts General Hospital
- Study coordinator: Wang, Cheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.