Investigating how a fatty acid helps reduce lung inflammation caused by ozone exposure
Official title: The role of endogenous docosahexaenoic acid in resolving ozone induced lung inflammation
Funded at Ohio State University · NIH-11042136 · Data updated 2026-11-12
This study is looking at how a fatty acid called DHA, found in certain foods, might help reduce lung inflammation caused by ozone pollution, which could be especially helpful for people with chronic lung diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | February 9, 2024 |
| Project end | May 4, 2025 |
| Funding year | 2025 |
| Award (this year) | $20,285 |
| NIH project number | 5F31ES036102-02 |
| Project ID | NIH-11042136 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic lung diseases who are exposed to ozone pollution.
✕Less likely to help
Patients with lung conditions not related to inflammation or those not exposed to ozone may not benefit from this research.
What this research studies
This research explores the effects of docosahexaenoic acid (DHA), a fatty acid, on lung inflammation triggered by ozone, a harmful air pollutant. The study focuses on how DHA can enhance the body's natural resolution mechanisms that help reduce inflammation and promote healing in the lungs. By examining the role of DHA in immune cells, particularly alveolar macrophages, the research aims to understand how dietary DHA could potentially mitigate the adverse effects of ozone exposure on lung health. Patients with chronic lung diseases may find this research particularly relevant as it investigates a dietary approach to improve their condition.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that help reduce lung inflammation and improve health outcomes for patients with chronic lung diseases.
How similar studies have gone: Previous research has shown that dietary supplementation with omega-3 fatty acids can positively influence inflammation, suggesting potential success for this approach.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Yaeger, Michael Jerome — Ohio State University
- Study coordinator: Yaeger, Michael Jerome
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.