Investigating how a drug affects glucose metabolism in Alzheimer's disease
Glycolysis and Alzheimer’s Disease
This study is looking at how a medication called terazosin might help protect against Alzheimer's disease by improving how the brain uses sugar for energy, and it's being tested in mice to see if it can make a difference.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10703424 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of glucose metabolism in Alzheimer's disease (AD) and how it contributes to neurodegeneration. The study will explore the effects of terazosin, a drug that enhances glycolysis, in animal models of AD. By administering terazosin to specific mouse models, researchers aim to quantify its engagement with a key enzyme involved in glucose metabolism and assess its potential protective effects against AD. The findings could provide insights into new therapeutic strategies for managing Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease or those diagnosed with early-stage Alzheimer's.
Not a fit: Patients with advanced Alzheimer's disease or those not responding to other treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that slow the progression of Alzheimer's disease.
How similar studies have performed: While this approach is novel in targeting glucose metabolism for Alzheimer's treatment, preliminary data suggest potential benefits from similar drug mechanisms.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Zhang, Qiang — University of Iowa
- Study coordinator: Zhang, Qiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.