Investigating how a diabetes medication affects sleep apnea and body fat.
Official title: Adipose Dysfunction, Imaging, Physiology, and Outcomes with SGLT2i's for Sleep Apnea: The ADIPOSA Study
Funded at Case Western Reserve University · NIH-10891363 · Data updated 2026-11-12
This study is looking at how a diabetes medication might help people with obstructive sleep apnea feel better, and it's for overweight or obese adults who have been diagnosed with moderate to severe sleep apnea.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | July 20, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $679,601 |
| NIH project number | 5R01HL163627-02 |
| Project ID | NIH-10891363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are overweight or obese adults aged 21 and older who have been diagnosed with moderate to severe obstructive sleep apnea.
✕Less likely to help
Patients who are not overweight or obese, or those with mild sleep apnea, may not benefit from this research.
What this research studies
This research explores the effects of a diabetes medication called SGLT2 inhibitors on patients with obstructive sleep apnea (OSA). It involves a clinical trial with 164 overweight or obese adults who have been diagnosed with moderate to severe OSA. Participants will be randomly assigned to receive either the medication or a placebo for six months, during which various physiological and anatomical changes will be measured. The study aims to understand how this medication may improve sleep apnea symptoms and related health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from obstructive sleep apnea, potentially improving their quality of life and reducing associated health risks.
How similar studies have gone: While the use of SGLT2 inhibitors for diabetes management is well-established, their application in treating obstructive sleep apnea is a novel approach that has not been extensively tested.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Neeland, Ian Jason — Case Western Reserve University
- Study coordinator: Neeland, Ian Jason
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.