Investigating how a diabetes medication affects sleep apnea and body fat.
Adipose Dysfunction, Imaging, Physiology, and Outcomes with SGLT2i's for Sleep Apnea: The ADIPOSA Study
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10891363
This study is looking at how a diabetes medication might help people with obstructive sleep apnea feel better, and it's for overweight or obese adults who have been diagnosed with moderate to severe sleep apnea.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10891363 on ClinicalTrials.gov |
What this research studies
This research explores the effects of a diabetes medication called SGLT2 inhibitors on patients with obstructive sleep apnea (OSA). It involves a clinical trial with 164 overweight or obese adults who have been diagnosed with moderate to severe OSA. Participants will be randomly assigned to receive either the medication or a placebo for six months, during which various physiological and anatomical changes will be measured. The study aims to understand how this medication may improve sleep apnea symptoms and related health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are overweight or obese adults aged 21 and older who have been diagnosed with moderate to severe obstructive sleep apnea.
Not a fit: Patients who are not overweight or obese, or those with mild sleep apnea, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients suffering from obstructive sleep apnea, potentially improving their quality of life and reducing associated health risks.
How similar studies have performed: While the use of SGLT2 inhibitors for diabetes management is well-established, their application in treating obstructive sleep apnea is a novel approach that has not been extensively tested.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NEELAND, IAN JASON — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: NEELAND, IAN JASON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus