Investigating how a compound can prevent obesity-related liver issues in young baboons.
Evaluating PQQ for preventing maternal obesity-induced fetal programming of juvenile NAFLD in Papio anubis
['FUNDING_R01'] · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · NIH-11056011
This study is looking at how being overweight during pregnancy can affect the health of babies, especially their risk of developing liver problems later on, and it will test whether a special compound can help reduce these risks starting before birth.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-11056011 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how maternal obesity affects the development of metabolic diseases in offspring, particularly nonalcoholic fatty liver disease (NAFLD). By using a baboon model, the study aims to explore the impact of maternal diet on the microbiome and inflammation, which may lead to long-term health issues in the young. The researchers will evaluate the effectiveness of a compound called PQQ in mitigating these risks, potentially starting from the prenatal stage. This approach involves monitoring metabolic changes and health outcomes in juvenile baboons exposed to maternal obesity.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals with obesity who are at risk of having offspring with metabolic disorders.
Not a fit: Patients who are not pregnant or do not have a history of obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing liver disease in children born to obese mothers.
How similar studies have performed: Previous research has shown promising results in using similar dietary interventions in animal models, indicating potential for success in this approach.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JONSCHER, KAREN R — UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- Study coordinator: JONSCHER, KAREN R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.