Investigating how a compound called 3-hydroxybutyrate affects aging in yeast.
Official title: 3-hydroxybutyrate: an unexpected longevity factor in yeast
Funded at University of Virginia · NIH-11073407 · Data updated 2026-11-12
This study is looking at how a substance called 3-hydroxybutyrate (BHB) can help yeast live longer, especially when they are in a fasting state, and the findings might give us clues about how to promote longevity in humans too.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $236,918 |
| NIH project number | 1R21AG092022-01 |
| Project ID | NIH-11073407 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals interested in aging and longevity, particularly those with age-related health concerns.
✕Less likely to help
Patients with acute health conditions unrelated to aging may not benefit from this research.
What this research studies
This research explores the role of 3-hydroxybutyrate (BHB) in promoting longevity in yeast, a model organism for studying aging. The researchers have discovered that BHB can extend the lifespan of yeast cells, particularly under conditions that mimic fasting. By examining how BHB influences metabolic pathways and protein modifications associated with aging, the study aims to uncover new insights into the mechanisms of longevity. This could provide valuable information on how similar processes might work in humans.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing healthspan and longevity in humans.
How similar studies have gone: Previous research has shown that caloric restriction and other metabolic interventions can positively impact lifespan, suggesting potential for success with this novel approach.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Smith, Jeffrey Scott — University of Virginia
- Study coordinator: Smith, Jeffrey Scott
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.