Investigating how a common indoor fungus may influence Alzheimer's disease
The Role of Aspergillus versicolor and the Th2 Lung-Brain Axis in Alzheimer's Disease-like Neuropathology
This study is looking into whether breathing in a common fungus found in damp places could be linked to Alzheimer's disease, and it aims to help us understand how things in our environment might affect brain health, especially for those concerned about cognitive changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11013325 on NIH RePORTER |
What this research studies
This research explores the potential link between exposure to the fungus Aspergillus versicolor and the development of Alzheimer's disease (AD). It focuses on how inhaling this fungus, often found in damp indoor environments, may trigger immune responses that affect brain health. By studying both human cohorts and experimental models, the research aims to uncover the mechanisms through which environmental factors like air pollution and fungal exposure contribute to AD pathology. Patients may be involved in understanding how these exposures relate to cognitive changes and overall brain health.
Who could benefit from this research
Good fit: Ideal candidates for this research include elderly individuals, particularly those with a history of respiratory issues or exposure to damp indoor environments.
Not a fit: Patients who do not have any risk factors for Alzheimer's disease or respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing or mitigating Alzheimer's disease by addressing environmental risk factors.
How similar studies have performed: While the specific approach of linking Aspergillus versicolor to Alzheimer's is novel, there is emerging evidence suggesting that environmental factors, including air pollution, can impact cognitive health.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Oblak, Adrian Lynn — Indiana University Indianapolis
- Study coordinator: Oblak, Adrian Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.