Investigating how a collagen receptor affects brain tumor growth and immune response
Role of the collagen receptor LAIR-1 in glioma progression and the tumor immune microenvironment
This study is looking at how a specific protein called LAIR-1 affects the way immune cells respond to aggressive brain tumors, called high-grade gliomas, and hopes to find new ways to help the immune system fight these tumors better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11041156 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the collagen receptor LAIR-1 in the progression of high-grade gliomas, which are aggressive brain tumors. The study examines how collagen in the tumor environment influences immune cell behavior, particularly how it suppresses the immune response against the tumor. By analyzing the interactions between collagen and immune cells, the research aims to uncover mechanisms that could lead to new therapeutic strategies for glioma treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with high-grade gliomas who are seeking new treatment options.
Not a fit: Patients with low-grade gliomas or other types of brain tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with high-grade gliomas by enhancing anti-tumor immune responses.
How similar studies have performed: Other research has shown promising results in targeting immune responses in cancer, suggesting that this approach could be effective.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Lowenstein, Pedro R. — University of Michigan at Ann Arbor
- Study coordinator: Lowenstein, Pedro R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.