Investigating how a circadian clock gene affects memory problems in Alzheimer's disease
Circadian clock gene Rev-erb in memory dysfunction in Alzheimer's disease
This study is looking at how changes in our body's internal clock might affect memory problems in people with Alzheimer's, and it will test if fixing a specific gene can help improve thinking skills in mice with the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11019731 on NIH RePORTER |
What this research studies
This research explores the relationship between circadian rhythms and cognitive deficits in Alzheimer's disease. It focuses on the role of the Rev-erb gene in the brain's central circadian clock and how disruptions in this clock may lead to memory dysfunction. Using a mouse model of Alzheimer's, the study will assess whether restoring the Rev-erb gene can improve cognitive functions. The research aims to uncover the mechanisms by which circadian disruptions contribute to memory issues, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those experiencing cognitive deficits.
Not a fit: Patients with early-stage Alzheimer's disease who do not exhibit cognitive dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve memory and cognitive function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has indicated that circadian rhythm disruptions are linked to cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Sun, Zheng — Baylor College of Medicine
- Study coordinator: Sun, Zheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.