Investigating how a cellular mechanism affects tumor growth in oral cancer
ESCRT-dependent novel regulatory mechanism of EMT and tumorigenesis in oral cancer
This study is looking at how a protein called EGFR affects oral cancer and how certain processes in our cells can change its levels, with the goal of finding new ways to help people with this type of cancer feel better and live longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-11086677 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the Epidermal Growth Factor Receptor (EGFR) in oral squamous cell carcinoma (OSCC), a common type of oral cancer. It explores how the endosomal sorting complex for recruitment and transport (ESCRT) regulates EGFR levels and contributes to cancer progression and metastasis. By studying the mechanisms that control EGFR internalization and degradation, the research aims to uncover new therapeutic targets that could improve treatment outcomes for patients with OSCC. The approach includes laboratory experiments on cancer cell lines to observe the effects of manipulating specific proteins involved in this process.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with oral squamous cell carcinoma who may benefit from novel therapeutic strategies targeting EGFR.
Not a fit: Patients with other types of cancer or those without oral cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively target and reduce tumor growth in patients with oral cancer.
How similar studies have performed: Previous research has shown promising results in targeting EGFR in various cancers, indicating that this approach has potential for success in oral cancer as well.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Vasu, Chenthamarakshan — Medical University of South Carolina
- Study coordinator: Vasu, Chenthamarakshan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.