Investigating how a brain tissue secretion affects injury in newborns
Official title: Role of Choroid Plexus Autotaxin Secretion in Hemorrhage-Induced White Matter Injury
Funded at Boston Children's Hospital · NIH-11059040 · Data updated 2026-11-12
This study is looking at a substance called Autotaxin that comes from a part of the brain, to see how it affects brain injuries in newborns, especially those caused by bleeding, and hopes to find new ways to help improve brain development in babies who have these injuries.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $74,284 |
| NIH project number | 5F32NS134588-02 |
| Project ID | NIH-11059040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premature infants who have experienced brain injuries, particularly those with post-hemorrhagic hydrocephalus.
✕Less likely to help
Patients who are not premature or do not have any form of brain injury may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific secretion from the choroid plexus, called Autotaxin, in the context of brain injuries in newborns, particularly those caused by bleeding in the brain. The study examines how this secretion influences the development of white matter in the brain, which is crucial for proper brain function. By using mouse models, researchers will analyze the effects of Autotaxin on myelination and axonal injury, aiming to uncover potential therapeutic targets for treating white matter injuries associated with post-hemorrhagic hydrocephalus in premature infants.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve brain development and outcomes for premature infants suffering from brain injuries.
How similar studies have gone: Previous research has shown promising results in understanding the role of Autotaxin in brain development, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Hochstetler, Alexandra — Boston Children's Hospital
- Study coordinator: Hochstetler, Alexandra
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.