Investigating how a brain region affects fentanyl relapse behavior
Official title: A Novel Role of Interpeduncular Nucleus GLP-1Rs in Fentanyl Reinstatement
Funded at University of Pennsylvania · NIH-10885915 · Data updated 2026-11-12
This study is looking at how certain brain receptors might help reduce cravings for fentanyl in people recovering from addiction, with the hope of finding new ways to support those struggling with opioid use disorder.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31DA058451-02 |
| Project ID | NIH-10885915 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of fentanyl use disorder or those at risk of opioid relapse.
✕Less likely to help
Patients who are not affected by opioid use disorder or those who do not use fentanyl may not benefit from this research.
What this research studies
This research explores the neurobiological mechanisms behind fentanyl seeking behavior, particularly focusing on the role of glucagon-like peptide-1 receptors (GLP-1Rs) in the interpeduncular nucleus of the brain. By using animal models, the study examines how activating these receptors can reduce the desire to seek fentanyl after a period of abstinence. The findings aim to enhance our understanding of addiction and potentially lead to new treatments for opioid use disorder, specifically targeting fentanyl. The research involves administering a specific GLP-1R agonist to observe its effects on behavior related to fentanyl relapse.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that reduce relapse rates in individuals struggling with fentanyl addiction.
How similar studies have gone: Previous research has shown promising results in using GLP-1R agonists to influence addiction behaviors, suggesting that this approach may be effective.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Herman, Rachel Jaschik — University of Pennsylvania
- Study coordinator: Herman, Rachel Jaschik
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.