Investigating how a brain receptor affects sleep therapy for depression
Official title: Mechanistic clinical trial evaluating the role of the metabotropic glutamate receptor subtype 5 (mGluR5) in the antidepressant mechanism of Cognitive Behavioral Therapy for Insomnia (CBT-I)
Funded at State University New York Stony Brook · NIH-11128048 · Data updated 2026-11-12
This study is looking at how a brain receptor called mGluR5 might affect how well Cognitive Behavioral Therapy for Insomnia (CBT-I) helps adults who have both insomnia and depression, to see if improving sleep can also lift their mood.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | May 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $808,417 |
| NIH project number | 1R01MH137211-01A1 |
| Project ID | NIH-11128048 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing both depression and insomnia.
✕Less likely to help
Patients who do not have symptoms of depression or insomnia may not benefit from this research.
What this research studies
This research explores the relationship between a specific brain receptor, mGluR5, and the effectiveness of Cognitive Behavioral Therapy for Insomnia (CBT-I) in treating depression. It aims to understand how CBT-I, which focuses on improving sleep, can also alleviate depressive symptoms, particularly in adults who experience insomnia alongside depression. By examining the biological mechanisms involved, the study seeks to uncover how changes in mGluR5 levels may influence treatment outcomes. Patients participating in this research may undergo assessments related to their sleep patterns and depression severity as part of the trial.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for depression that incorporate sleep therapy, potentially enhancing recovery rates for patients.
How similar studies have gone: Previous research has shown promising results in understanding the role of mGluR5 in depression and sleep, indicating that this approach has potential based on earlier findings.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Delorenzo, Christine — State University New York Stony Brook
- Study coordinator: Delorenzo, Christine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.