Investigating how a brain protein affects recovery after a stroke
AQP4 and glymphatic function in post-stroke recovery
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10884254
This study is looking at how a special protein and a system in the brain that helps clear out waste can affect recovery after a stroke, with the hope of finding new ways to help stroke patients heal better and avoid long-term problems.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10884254 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of aquaporin-4 (AQP4), a protein involved in brain water regulation, and the glymphatic system, which helps clear waste from the brain, in the recovery process following a stroke. By developing advanced MRI techniques, the study aims to assess how these factors contribute to brain edema, a common and dangerous complication after a stroke. The findings could lead to new therapeutic targets that enhance recovery and reduce long-term disability for stroke patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have experienced a stroke.
Not a fit: Patients who have not had a stroke or those with pre-existing severe neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery strategies for stroke patients, potentially reducing disability and enhancing quality of life.
How similar studies have performed: Previous research has shown promise in understanding the glymphatic system's role in brain health, suggesting that this approach could yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YU, XIN — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: YU, XIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury